Jobbeschreibung
Vanudis GmbH is a young company, founded in mid-2022 and based in Heidelberg. Building on extensive experience gained at renowned research institutions both nationally and internationally, a multidisciplinary team with diverse skills and talents has come together to work towards significantly improving the lives of patients with cancer and other serious illnesses. As a growing biopharmaceutical company, we aim to successfully implement this goal into practice.
Do you want to contribute to this goal, bringing in your personal expertise and further developing yourself? Then, we should get to know each other.
VANUDIS has developed patient derived proprietary antibody phage display and cell surface display libraries from B cell repertiores of tumor draining lymph nodes (Lymph Node Derived Antibody Libraries, LyNDAL). Antibodies with therapeutic potential are selected from these libraries and further developed into viable immunotherapeutics.
- Design and execute antibody discovery campaigns using mammalian cell and phage display
- Continuously increase the size of LyNDAL by cloning additional B cell repertoires from patient-derived tumor draining lymph nodes into phage and mammalian display vectors
- Conduct high-throughput screening (HTS) of antibody display campaign outputs using ELISA and flow cytometry
- Perform biochemical, biophysical and functional characterization of selected antibodies according to respective lead candidate requirements
- Work on multiple projects simultaneously, ensuring timely delivery of potential therapeutic leads to respective drug development groups
- Document work in an electronic lab notebook, analyse and interpret generated data, and present them in meetings in an organized manner
- Innovate and establish new strategies to address challenging targets
- Completed PhD in the field of immunology, immuno-oncology, biomedicine, or a related discipline with 2+ years of post-doctoral experience, preferably in Pharma or Biotech industry
- At least 1 year direct experience with antibody display technologies and selection methodologies
- In-depth knowledge and hands-on experience with molecular biology techniques, including RT-PCR, PCR, overlap extension PCR, cloning, primer design, and in-silico DNA construct design
- Experience in cloning, expression, and purification of proteins/antibodies in bacterial and mammalian cells
- Experience in flow cytometry
- Hands-on and problem-solving mentality
- Effective resource and time management skills
- Proficient in Microsoft Word, Excel, and PowerPoint, and preferably experienced in maintaining an electronic lab notebook (ELN)
- Ability to adapt well to rapidly changing goals and research directions
- Ability to work collaboratively with teams
- Excellent English oral and written communication skills
- Motivation and interest in making a difference with meaningful work to improve patient's life
Working environment: Flexible working time and 30 days of vacation alongside a company pension plan. As a member of our international project team, you will work on projects within the framework of a structured development plan. Our company structure is characterized by flat hierarchies and short decision-making processes, enabling agility. We provide long-term professional development opportunities and state-of-the-art equipment as standard.
Central Location: Our premises in the Bahnstadt of Heidelberg offer an appealing work atmosphere and ideal access to public transportation. There are plenty of culinary, cultural, and sports options available for breaks and after work.
How to apply:
If you're intrigued by the challenge of shaping an innovative company successfully, we look forward to receiving your application! Please send your application documents directly online to [email protected].
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