Jobbeschreibung
The Fraunhofer-Gesellschaft currently operates 76 institutes and research institutions throughout Germany and is the world's leading applied research organization. Around 32 000 employees work with an annual research budget of 3.4 billion euros.
We offer a postdoc position in a project aiming at the development of organoid models for inflammatory bowel diseases. The project is a collaboration between the Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, the Medical Campus of the Goethe University, and Sanofi. The position will be based in Frankfurt am Main.
- Establish co-culture strategies of patient-derived organoids with autologous immune cells, mimicking the complexity of the human intestine during inflammation and implementation as a pharmacological tool for drug testing in preclinical research
- Develop a workflow analysis to investigate crosstalk between human colonic epithelium and immune cells
- Molecularly and functionally characterize co-culture models using advanced technologies such as single-cell RNA-sequencing and 3D high-throughput imaging systems
- PhD in biology, biochemistry, molecular biology, cell biology, immunology, or a related discipline
- Experience with primary cell culture, profound knowledge of molecular, cell biology and immunology techniques with hands-on experience
- Advantageous but not required: Expertise in organoid technology, high-throughput imaging or patient biosample processing
- Ability to work in a multidisciplinary and international team of scientists
- Excellent written and oral communication skills
- Independent problem solving and systematic data-driven experimental design and execution
- Fluency in English, German is a plus
- A multidisciplinary project with a strong focus on applied science
- Close collaboration with clinical researchers and a pharmaceutical industry partner
- Opportunities to present and publish your findings
- High degree of independence and autonomy
- Support for continuing education and further qualification