Jobbeschreibung
"Knowledge becomes health" - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge. The University Hospital Frankfurt has existed since 1914. Our around 7,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative departments. The close connection of health care with research and teaching, as well as a climate of collegiality, internationality, and cross-professional cooperation characterize the university hospital. PhD Student - ,,CRISPR-based optimization of CAR NK cell therapy for pediatric AML" (We are targeting applicants of all genders) Part Time (65% per Week) | limited ro 2 years | Announcement number: 470-2024 We are seeking a highly motivated PhD student to join our Leukemia Research Group at the Department of Experimental Pediatric Hematology & Oncology (Director: Prof. Dirk Heckl) and the Department of Pediatrics (Director: Prof. Jan-Henning Klusmann). Our joint labs are at the forefront of pediatric leukemia research, focusing on genetic and epigenetic analyses and pioneering innovative molecularly-guided therapeutic approaches. For an insight into the University Hospital Frankfurt, click here . Your role Pediatric acute myeloid leukemia (AML) comprises a group of genetically and morphologically heterogenous malignancies originating from early hematopoietic progenitor cells. Where eure rates of pediatric cancers exceed 80% for most tumor entities, AML still has a comparably poor prognosis in particular for those children with high-risk genetics. lmmunotherapy is an emerging field with intriguing potential in cancer therapy that is expected to improve treatment outcome of pediatric AML. Cellular immunotherapy with chimeric antigen receptor {CAR) T-cells has already shown amazing results in B-cell malignancies, and applications for solid tumor entities are rapidly evolving. Combining immunotherapy with genome editing, another transformative technology in biomedical research and medicine, has been key for the advances made in the field. However, with a major focus of immunotherapy being placed on CAR T-cells, alternative promising cell sources -like natural killer (NK) cells- are lacking behind. In particular the safety profile of NK cells, their ability of non-specific tumor killing and low rejection potential are highly beneficial for cancer treatments targeting essential cell types of the body. While recent applications of NK cell therapies for hematopoietic malignancies and solid tumors have shown highly promising results, further optimization will accelerate this breakthrough cancer therapy. Due to the inherent resistance to viral transduction, efforts to genetically optimize NK cells for therapeutic applications have so far been limited. Yet, recent advances in synthetic lentiviral envelope pseudotyping, transient genome-editing tool delivery, and new genome-editing technologies are now opening new windows for cellular genetic modifications of NK cells. This project aims to leverage these technical advances and a unique resource of pediatric patient samples and patient-derived xenograft models to adopt and optimize CAR NK cellbased immunotherapy for pediatric AML. The project will thereby overcome current hurdles to tackle myeloid malignancies and will contribute to the development of personalized cancer therapies. Who you are Master's degree in life sciences or equivalent Passion for discovery of novel therapy approaches and epigenetic mechanisms of gene regulation Collaborative spirit & good communication skills Experience in basic laboratory techniques (i.e. molecular biology, flow cytometry etc.) Proficiency in spoken and written English Due to legal regulations, valid proof of measles immunity / measles vaccination is required. What we offer Collective agreement: In addition to an attractive salary based on a collective agreement with an annual special payment, you benefit from long-term security through company pension schemes Collaborative spirit: Experience in basic laboratory techniques (i.e. molecular biology, flow cytometry etc.), Proficiency in spoken and written English, Excellent scientific environment & dedicated mentoring, Training in novel cutting edge techniques to study epigenetic mechanisms in leukemia cells, Collaboration opportunities with national & international world-leading laboratories, Participation in training and qualification programs of the MSNZ and the Goethe University Mobility: Free public transport in all Hessen (Free State Ticket Hessen) Campus: Our attractive university hospital campus offers a modern cafeteria, various cafes, and opportunities to rest in numerous green spaces. A walk on the riverside of the Main offers relaxation during breaks Work-Life-Balance: Part-time employment is possible, we offer childcare in our daycare center (if you have any questions, please contact
[email protected] ), child care during holidays Health Promotion: Benefit from our attractive health offers. We offer regular online and face-to-face courses on nutrition, relaxation, sports and exercise. Professional development: Internal and external training for your professional development Any questions? Many answers can be found in our FAQs for new employees. If you have any further questions, please do not hesitate to contact us. Women are underrepresented in these positions at the University Hospital Frankfurt. Applications from women are therefore particularly welcome. Disabled applicants are preferred if they have the same personal and professional qualifications. Join our team Use the time until July 3, 2024 to apply. Please submit your online application including a possible starting date and your salary expectations. For further information regarding the position and project, please contact Ms. Hugenberg (
[email protected] ) or Ms. Kunz (
[email protected] ). Apply now Universitätsklinikum Frankfurt | Recruiting Team | Theodor-Stern-Kai 7 | 60590 Frankfurt am Main | Bitte reichen Sie Ihre Bewerbung ausschließlich über den Button »Online bewerben« ein. Rückfragen können Sie gerne an
[email protected] richten. Bitte beachten Sie, dass keine Unterlagen zurückgeschickt werden. | Folgen Sie uns auf Instagram ( @ukf_karriere ); XING , LinkedIn .
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