Job Description
"Knowledge becomes health" - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge. The University Hospital Frankfurt has existed since 1914. Our around 8,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative departments. The close connection of health care with research and teaching, as well as a climate of collegiality, internationality, and cross-professional cooperation characterize the university hospital. PhD Student Position in HBV and Liver Fibrosis Research (We are targeting applicants of all genders) Part Time (26h/week) | limited to 12 months | Announcement number: 131-2025 The Department of Gastroenterology and Hepatology at Goethe University Hospital Frankfurt offers comprehensive diagnostic and therapeutic services for liver and digestive diseases. The research group led by Dr. Görgülü, Clinician Scientist, is part of the DFG-funded INDEEP program and focuses on understanding the impact of Hepatitis B Virus (HBV) mutations on liver fibrosis and inflammatory processes. Our lab operates within an innovative research environment and is embedded in a strong collaborative network that includes both national and international partners. We are supported by grants from the German Research Foundation (DFG) and Goethe University, allowing us to conduct cutting-edge translational research. Our team employs state-of-the-art technologies, including multiplex fluorescent-bead assays, phosphoblotting, and co-culture systems with human immune cells, to analyze the role of HBV in cellular signaling pathways, immune responses, and fibrosis development. Specifically, we investigate kinase signaling pathways, cytokine profiles, and receptor expression patterns, aiming to uncover new insights into HBV-induced liver pathology and to explore potential therapeutic targets. We are seeking a highly motivated PhD student to join our team. This position offers an exceptional opportunity to work on a clinically relevant project with direct implications for the management of chronic HBV infections. For an insight into the University Hospital Frankfurt, click here . Your role Conduct analysis of upregulated/dysregulated kinases using kinase array validation Examine the effects of HBV on hepatic stellate cell (HSC) proliferation through ERK/MAPK/PDGF signaling, assessing specific fibrosis markers Profile cytokine/chemokine production in HSCs after transfection with HBV constructs and analyze HBV-transfected HSC impact on T-cell activation and regulatory T-cell induction in co-culture with human PBMCs Investigate insulin receptor signaling modulation by different HBV mutants, focusing on insulin receptor surface expression and IRS1/2 phosphorylation Independently plan, execute, and analyze experiments using advanced molecular and cellular biology techniques (e.g., tissue culture, flow cytometry, Western blotting) Who you are Master degree or equivalent in molecular medicine, biology, biochemistry or related fields Solid hands-on research experience in basic cell biology, biochemistry and molecular biology methods Fascination and motivation for biomedical research in the field of virology Enthusiasm to learn and implement novel technologies High motivation for experimental lab work and data presentation Ability to work in a team, sense of responsibility and proactivity Basic knowledge in MS office (Word, Excel) Fluent English Due to legal regulations, valid proof of measles immunity / measles vaccination is required. What we offer Collective agreement: In addition to an attractive salary based on a collective agreement (TVGU E13 (65%)) with an annual special payment, you benefit from long-term security through company pension schemes Mobility: Free public transport in all Hessen (Free State Ticket Hessen) Working Environment: Young and enthusiastic working environment in an international, multidisciplinary team, Interaction with the Paul Ehrlich Institute (Langen, Hessen) Funding: Funding secured for at least 3 years and extension possible if needed Campus: Our attractive university hospital campus offers a modern cafeteria, various cafes, and opportunities to rest in numerous green spaces. A walk on the riverside of the Main offers relaxation during breaks Work-Life-Balance: Part-time employment is possible, we offer childcare in our daycare center (if you have any questions, please contact UKF-Familienservice), child care during holidays Health Promotion: Benefit from our attractive health offers. We offer regular online and face-to-face courses on nutrition, relaxation, sports and exercise. Professional development: Internal and external training for your professional development Any questions? Many answers can be found in our FAQs for new employees. If you have any further questions, please do not hesitate to contact us. Women are underrepresented in these positions at the University Hospital Frankfurt. Applications from women are therefore particularly welcome. Disabled applicants are preferred if they have the same personal and professional qualifications. Join our team Use the time until February 10, 2025 to apply. Please submit your online application including a possible starting date and your salary expectations. For further information regarding the position and project, please contact Dr. Esra Görgülü via mail:
[email protected] or Mrs. Willenberger via phone 069-6301-5122. Apply now Universitätsmedizin Frankfurt | Recruiting Team | Theodor-Stern-Kai 7 | 60590 Frankfurt am Main | Bitte reichen Sie Ihre Bewerbung ausschließlich über den Button „Online bewerben“ ein. Rückfragen können Sie gerne an
[email protected] richten. Bitte beachten Sie, dass keine Unterlagen zurückgeschickt werden. | Folgen Sie uns auf Instagram ( @unimedizin-ffm ); XING , LinkedIn .
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