Job Description
Tacalyx is a biopharmaceutical company developing innovative therapeutics to target tumorassociated carbohydrate antigens (TACAs). To strengthen our team in Berlin-Adlershof, we are seeking an experienced, enthusiastic, and self-driven Research scientist.
Research Scientist (m/f/d) Cellular Assay Development
The major focus of this position is the development of cellular assays which will be used for antibody characterization.
- Development/establishment of in vitro cancer models (2D and 3D)
- Generation and characterization of stable knock-out cell lines (e.g. using CRISPR/Cas) and knock-in cell lines
- Design and performance of functional cellular assays to validate mAb candidates
- Developing and executing experiments to explore the activity and mode of action of mAb candidates
- Analysis of carbohydrate structures in the extracellular space
- Establishment, optimization, characterization, and validation of cell-based analytical methods
- Analysis and interpretation of data based on project needs (R, Prism, Python)
- Keep up to date on scientific advances in the field from literature and conferences
- PhD degree (obtained not later than 3 years ago) in Life Sciences with focus on immunology/cell biology/oncology
- Extensive hands-on experience in cell line engineering and flow cytometry is a must, hands-on experience in primary immune cell culture is an asset
- Significant experience in design, execution, and analysis of cell-based assays for proliferation, cell death and killing, adhesion, migration and other immune-oncological assays is desired
- Significant experience in 3D cell culture and extracellular vesicle isolation and analysis is a strong plus
- Data analytics skills using R or Python is a plus
- Ability to design and execute experiments, critically interpret experimental results, and present data in a meaningful manner
- A high level of communication in English and a work permit for Germany (for non-EU applicants) is mandatory
- A permanent position with a competitive salary as well as excellent opportunities for professional and personal development
- A diverse, international workforce with a dynamic working environment that fosters creativity, innovation and teamwork
- Annual bonus payment depending on the achievement of goals
- Regular company and team events
- Free “Jobticket” (allows the holder to use local public transport anywhere in the country)